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Infectious Diseases

Principal Investigators

Subramanian Dhandayuthapani, Ph.D.

Associate Professor


Department of Biomedical Sciences
Center of Excellence in Infectious Diseases
Paul L. Foster School of Medicine
Texas Tech University Health Sciences Center
5001 El Paso Drive, El Paso, TX 79905
Phone: (915) 215-4239


Research Interest

Dr. Pani's laboratory studies the pathogenic mechanisms of Mycobacterium tuberculosis and Mycoplasma genitalium. M. tuberculosis is the etiological agent of human 'tuberculosis' which has the ability to survive and replicate within hostile macrophages, and to lead a dormant life inside 'tubercle granulomas'. M. genitalium is a sexually transmitted pathogen which survives and persists within host urogenital epithelial cells.

He employs multiple approaches to dissect the mechanisms behind intracellular survival and persistence of both species. Some important projects addressing these issues are: a) role of antioxidants of M. tuberculosis and M. genitalium in the evasion of host generated oxidative radicals, b) role of regulatory molecules of M. tuberculosis and M. genitalium in the persistence of these species within human cells, and c) modulation of host microRNA by M. tuberculosis and M. genitalium for host survival and persistence.

Another important project that is currently underway in his lab is the "interaction of M. genitalium with HIV-1". Of late, there has been increasing evidences that M. genitalium co-infection promotes HIV-1 transmission in women.

In addition to above, research in Dr. Pani's laboratory focuses on the development of genetically engineered vaccines to tuberculosis (TB). This includes the improvement of existing BCG vaccines through recombinant technology, generation of M. tuberculosis vaccine candidates by genetic manipulations, and development of recombinant booster vaccines to TB using Bacillus subtilis spores.

Dr. Pani obtained his Ph.D from University of Madras, Madras, India, and he did postdoctoral research at The National Institute of Leprosy Research, Tokyo, Japan, and at The University of Texas Health Science Center, San Antonio, Texas. He was a faculty at the University of Texas Health Science Center, San Antonio, Texas before joining at TTUHSC.


Staff

Kishore Das, Ph.D

Post Doctoral Research Associate

(915) 215-4573

Saikolappan Sankaralingam, Ph.D.

Post Doctoral Research Associate

(915) 215-4571

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